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- If you have heart-related issues, it might expand your hazard for cardiovascular failure or stroke. However, these two apparently differentiating conditions are nearer family than envisioned, and are in reality two of a kind. The medication may seldom cause an agonizing or delayed erection. Some ailments preclude you from taking Sildenafil. These are sensitivities to prescriptions or foods, twisted penis, platelet issues, for example, leukemia, sickle cell pallor and different myeloma, history of drawn out or painful erection, history of eye issues, for example, macular degeneration, retinitis pigmentosa, optic neuropathy or unexpected vision misfortune, hearing issues, history of kidney issue, liver issue, respiratory failure, stroke or genuine unpredictable heartbeat.